Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 14/20 | 0.86 |
| ▸ | LTB4R2 | Q9NPC1 | 13/20 | 0.86 |
| ▸ | PLA2G4A | P47712 | 4/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023408 | 0.93 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL9022642 | 0.93 | LTB4R (0.74) | LTB4RLTB4R2PLA2G4APLA2G2AHTR6 | |
| SCHEMBL9023208 | 0.91 | LTB4R (0.72) | LTB4RLTB4R2PLA2G4AHTR6 | |
| SCHEMBL9526751 | 0.89 | LTB4R (0.92) | LTB4RLTB4R2PLA2G4AHTR6 | |
| SCHEMBL9023465 | 0.89 | LTB4R (0.92) | LTB4RLTB4R2PLA2G4A | |
| SCHEMBL9022788 | 0.86 | LTB4R (0.88) | LTB4RLTB4R2PLA2G2A | |
| SCHEMBL9023265 | 0.86 | LTB4R (0.88) | LTB4RLTB4R2HTR6 | |
| SCHEMBL9023211 | 0.85 | LTB4R (0.86) | LTB4RLTB4R2 | |
| SCHEMBL9023728 | 0.85 | LTB4R (0.85) | LTB4RLTB4R2HTR6 | |
| SCHEMBL9022843 | 0.84 | LTB4R (0.84) | LTB4RLTB4R2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548250-B1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE POULENC RORER INT (US) | 1996-03-27 | — | — | EP | disclosed |
| US-5468898-A | Substituted naphthylene compounds exhibiting selective leukotriene B4 antagonist activity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-11-21 | — | — | US | disclosed |