Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 16/20 | 0.92 |
| ▸ | LTB4R2 | Q9NPC1 | 15/20 | 0.92 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | PPARD | Q03181 | 1/20 | 0.55 |
| ▸ | PPARA | Q07869 | 1/20 | 0.55 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023408 | 0.96 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL9023465 | 0.93 | LTB4R (0.92) | LTB4RLTB4R2PLA2G4A | |
| SCHEMBL9526029 | 0.92 | LTB4R (0.77) | LTB4RLTB4R2PPARGPPARDPPARA | |
| SCHEMBL9022788 | 0.90 | LTB4R (0.88) | LTB4RLTB4R2 | |
| SCHEMBL9023728 | 0.90 | LTB4R (0.85) | LTB4RLTB4R2HTR6 | |
| SCHEMBL9023265 | 0.90 | LTB4R (0.88) | LTB4RLTB4R2HTR6 | |
| SCHEMBL9023696 | 0.89 | LTB4R (0.86) | LTB4RLTB4R2PLA2G4AHTR6 | |
| SCHEMBL9023211 | 0.89 | LTB4R (0.86) | LTB4RLTB4R2 | |
| SCHEMBL9022843 | 0.87 | LTB4R (0.84) | LTB4RLTB4R2HTR6 | |
| SCHEMBL9023363 | 0.86 | LTB4R (0.79) | LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548250-A4 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY | — | 1993-10-27 | — | — | EP | disclosed |
| EP-0548250-A1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY. | RHONE POULENC RORER INT (US) | 1993-06-30 | — | — | EP | disclosed |
| WO-1992004321-A1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-03-19 | — | — | WO | disclosed |