Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9796682 | 0.79 | KDM4E (0.31) | POLBHCAR2 | |
| SCHEMBL746011 | 0.76 | CYP11B1 (0.45) | CHRNB2CHRNA4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL16195584 | 0.69 | CYP11B2 (0.40) | CHRNB2CHRNA4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL24503465 | 0.68 | CHRNB2 (0.36) | CHRNB2CHRNA4SLC6A4 | |
| SCHEMBL22004708 | 0.68 | POLB (0.35) | SLC6A4POLBHCAR2 | |
| SCHEMBL21844997 | 0.67 | CHRNA1 (0.30) | CHRNB2CHRNA4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL3941090 | 0.66 | POLB (0.35) | CHRNB2CHRNA4SLC6A4POLBHCAR2 | |
| SCHEMBL23532468 | 0.66 | SLC6A2 (0.46) | CHRNB2CHRNA4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL23532467 | 0.66 | SLC6A2 (0.46) | CHRNB2CHRNA4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL5737267 | 0.66 | POLB (0.32) | POLBHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533344-B1 | Methanoanthracenes as dopamine antagonists | ZENECA LTD (GB) | 1996-10-16 | — | — | EP | disclosed |
| EP-0533344-A1 | Methanoanthracenes as dopamine antagonists | ZENECA LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |