Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 4/20 | 0.37 |
| ▸ | NQO1 | P15559 | 2/20 | 0.37 |
| ▸ | TOP2A | P11388 | 6/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | HEXA | P06865 | 1/20 | 0.33 |
| ▸ | HEXB | P07686 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025524 | 0.96 | TOP2A (0.38) | NQO2NQO1TOP2AHEXAHEXB | |
| SCHEMBL9025183 | 0.92 | NQO2 (0.38) | NQO2NQO1TOP2AHASPINDYRK2 | |
| SCHEMBL9024397 | 0.91 | TOP2A (0.40) | NQO2NQO1TOP2AHEXAHEXB | |
| SCHEMBL9023748 | 0.90 | NQO2 (0.40) | NQO2NQO1 | |
| SCHEMBL9024127 | 0.88 | TOP2A (0.40) | NQO2NQO1TOP2ADYRK3RPS6KB1 | |
| SCHEMBL9024054 | 0.86 | TOP2A (0.38) | NQO2TOP2AHEXAHEXBHASPIN | |
| SCHEMBL9023814 | 0.84 | NQO2 (0.36) | NQO2NQO1TOP2A | |
| SCHEMBL9024018 | 0.84 | NQO2 (0.38) | NQO2NQO1TOP2ADYRK3RPS6KB1 | |
| SCHEMBL9023958 | 0.83 | TOP2A (0.42) | NQO2NQO1TOP2ADYRK3RPS6KB1 | |
| SCHEMBL8545959 | 0.83 | NQO2 (0.38) | NQO2NQO1TOP2ADYRK3RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5079358-A | Humans; leukemia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-07 | — | — | US | disclosed |