Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | CDK8 | P49336 | 2/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22970835 | 0.85 | CDK2 (0.39) | KDRCDK5DYRK1ACDK2CHEK1 | |
| SCHEMBL1822483 | 0.81 | KMT2A (0.50) | FDPSEGFRKDRCDK5DYRK1A | |
| SCHEMBL34467229 | 0.80 | EGFR (0.56) | FDPSEGFRALDH1A1CYP2A6F12 | |
| SCHEMBL6175758 | 0.80 | EGFR (0.56) | FDPSEGFRALDH1A1CYP2A6F12 | |
| SCHEMBL3800165 | 0.80 | GSK3A (0.61) | KDRCDK5DYRK1ACDK2CHEK1 | |
| SCHEMBL22970735 | 0.79 | DYRK1A (0.47) | EGFRKDRCDK5DYRK1ACDK2 | |
| SCHEMBL1704286 | 0.79 | KDR (0.39) | EGFRKDRCDK5DYRK1ACDK2 | |
| SCHEMBL27420834 | 0.79 | SMN1; SMN2 (0.55) | KDRCDK5DYRK1ACDK2CHEK1 | |
| SCHEMBL2075255 | 0.77 | TGFBR1 (0.48) | FDPSEGFRKDRCDK5DYRK1A | |
| SCHEMBL6831390 | 0.76 | EGFR (0.57) | EGFRKDRDYRK1AMAP4K4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |