Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902433 | 0.79 | FDPS (0.43) | KDRALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL901984 | 0.76 | IDH2 (0.42) | ALDH1A1 | |
| SCHEMBL1704285 | 0.71 | KDR (0.48) | KDRALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL27420834 | 0.71 | SMN1; SMN2 (0.55) | KDRALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL1704403 | 0.71 | KARS1 (0.47) | KDRALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL901654 | 0.69 | KDR (0.47) | KDRALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL902727 | 0.69 | CHEK1 (0.56) | KDRALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL6831390 | 0.69 | EGFR (0.57) | KDRDYRK1AMAP4K4PIM1CDK8 | |
| SCHEMBL1702373 | 0.69 | TDP1 (0.41) | KDRALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL22970835 | 0.68 | CDK2 (0.39) | KDRALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |