Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9368600 | 0.80 | NPSR1 (0.41) | NPSR1ALDH1A1HPGDL3MBTL1MCL1 | |
| SCHEMBL9024339 | 0.78 | NPSR1 (0.70) | NPSR1ALDH1A1HPGDL3MBTL1MCL1 | |
| SCHEMBL9025057 | 0.78 | TNKS2 (0.42) | NPSR1ALDH1A1HPGDHTTKMT2A | |
| SCHEMBL9025566 | 0.76 | KDM4E (0.51) | NPSR1ALDH1A1HPGDHTTKMT2A | |
| SCHEMBL9024465 | 0.67 | PKM (0.40) | ALDH1A1HPGDHTTHCAR2LMNA | |
| SCHEMBL5957180 | 0.65 | NPSR1 (0.51) | NPSR1ALDH1A1HPGDL3MBTL1MCL1 | |
| SCHEMBL9025130 | 0.65 | NPSR1 (0.37) | NPSR1ALDH1A1HPGDL3MBTL1MCL1 | |
| SCHEMBL15556424 | 0.64 | CSNK2A1 (0.44) | NPSR1ALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL2897468 | 0.64 | KDM4E (0.55) | NPSR1ALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL20470626 | 0.63 | MAPT (0.41) | NPSR1ALDH1A1HPGDL3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611368-B1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSIN II ANTAGONISTS | AMERICAN HOME PROD (US) | 1996-02-07 | — | — | EP | disclosed |
| EP-0611368-A1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSINE II ANTAGONISTS. | AMERICAN HOME PROD (US) | 1994-08-24 | — | — | EP | disclosed |
| US-5336677-A | ANTAGONIST OF ANGIOTENSIN II | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-08-09 | — | — | US | disclosed |
| WO-1993008169-A1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSINE II ANTAGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-29 | — | — | WO | disclosed |