Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | KDM5A | P29375 | 2/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19503077 | 0.75 | ALDH1A1 (0.50) | HPGDSMN1; SMN2ALDH1A1LMNAKDM5A | |
| SCHEMBL24900017 | 0.73 | KDM5B (0.41) | HPGDSMN1; SMN2ALDH1A1LMNAKDM5A | |
| SCHEMBL8515729 | 0.69 | L3MBTL1 (0.48) | HPGDALDH1A1LMNAHTTKDM5B | |
| SCHEMBL9025057 | 0.69 | TNKS2 (0.42) | PKMHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL15556424 | 0.69 | CSNK2A1 (0.44) | PKMHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9025566 | 0.68 | KDM4E (0.51) | PKMHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL20470626 | 0.68 | MAPT (0.41) | PKMHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL11780913 | 0.67 | HPGD (0.44) | PKMHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9024628 | 0.67 | NPSR1 (0.60) | PKMHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL13605206 | 0.66 | SMPD3 (0.35) | PKMHPGDALDH1A1HTTHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0611368-B1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSIN II ANTAGONISTS | AMERICAN HOME PROD (US) | 1996-02-07 | — | — | EP | disclosed |
| EP-0611368-A1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSINE II ANTAGONISTS. | AMERICAN HOME PROD (US) | 1994-08-24 | — | — | EP | disclosed |
| US-5336677-A | ANTAGONIST OF ANGIOTENSIN II | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-08-09 | — | — | US | disclosed |
| WO-1993008169-A1 | SUBSTITUTED AMINOPYRIMIDINES AS ANGIOTENSINE II ANTAGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-29 | — | — | WO | disclosed |