Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.34 |
| ▸ | PYGL | P06737 | 2/20 | 0.32 |
| ▸ | PYGM | P11217 | 2/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | TYMS | P04818 | 2/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | CMA1 | P23946 | 2/20 | 0.30 |
| ▸ | AHR | P35869 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9405612 | 0.83 | CA9 (0.38) | TDP2CA9TGM2CES1ADRA2A | |
| SCHEMBL15964659 | 0.83 | CMA1 (0.50) | TDP2CA9TGM2CES1ADRA2A | |
| SCHEMBL18743979 | 0.83 | HTR5A (0.40) | CA9SRD5A1DDB1CRBN | |
| SCHEMBL9405728 | 0.83 | TRPV1 (0.40) | CA9SRD5A1DDB1CRBN | |
| SCHEMBL9405624 | 0.83 | AHR (0.50) | SRD5A1PYGLPYGMDDB1CRBN | |
| SCHEMBL9025361 | 0.79 | SRC (0.45) | DDB1CRBN | |
| SCHEMBL15414847 | 0.79 | TDP2 (0.42) | TDP2CRBN | |
| SCHEMBL7086240 | 0.78 | NPC1 (0.52) | PYGLPYGMCRBNAHR | |
| SCHEMBL2060515 | 0.78 | CRBN (0.43) | TDP2ADRA2APNMTADRA2BADRA2C | |
| SCHEMBL2616856 | 0.74 | CA9 (0.62) | TDP2CA9SMYD3CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513974-B1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO INC (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5310737-A | Benzo-fused lactams that promote the release of growth hormone | MERCK & CO., INC. (US) | 1994-05-10 | — | — | US | disclosed |
| US-5206235-A | Animal growth regulators; stimulants | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0513974-A1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016524-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |