Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 14/20 | 0.41 |
| ▸ | NQO1 | P15559 | 7/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023931 | 0.93 | NQO2 (0.47) | NQO2NQO1MITFFGFR1KDR | |
| SCHEMBL9023958 | 0.93 | TOP2A (0.42) | NQO2NQO1MITFTOP2AMEN1 | |
| SCHEMBL9023796 | 0.90 | NQO2 (0.47) | NQO2NQO1MITFSMARCA2KEAP1 | |
| SCHEMBL9023748 | 0.90 | NQO2 (0.40) | NQO2NQO1MITFFGFR1KDR | |
| SCHEMBL9024127 | 0.89 | TOP2A (0.40) | NQO2NQO1TOP2AMEN1NPC1 | |
| SCHEMBL9024639 | 0.88 | NQO2 (0.42) | NQO2NQO1MITFSMARCA2KEAP1 | |
| SCHEMBL9023350 | 0.87 | TOP2A (0.38) | NQO2NQO1TOP2AMEN1NPC1 | |
| SCHEMBL9024018 | 0.86 | NQO2 (0.38) | NQO2NQO1MITFTOP2AMEN1 | |
| SCHEMBL8547450 | 0.85 | NQO1 (0.43) | NQO2NQO1MITFSMARCA2KEAP1 | |
| SCHEMBL9023814 | 0.85 | NQO2 (0.36) | NQO2NQO1MITFTOP2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | disclosed |
| EP-0347749-A2 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-27 | — | — | EP | disclosed |