Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 11/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 9/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10188701 | 0.82 | ATR (0.62) | ATRPARP1PARP2DGAT1DHODH | |
| SCHEMBL902484 | 0.74 | DGAT1 (0.64) | DGAT1 | |
| SCHEMBL14971969 | 0.73 | DGAT1 (0.75) | DGAT1 | |
| SCHEMBL18790540 | 0.70 | DHODH (0.47) | DGAT1DHODHRAF1 | |
| SCHEMBL902783 | 0.70 | DGAT1 (0.45) | DGAT1 | |
| SCHEMBL18790847 | 0.69 | NPC1 (0.45) | DGAT1DHODHRAF1 | |
| SCHEMBL901149 | 0.68 | DGAT1 (0.77) | DGAT1 | |
| SCHEMBL505903 | 0.68 | DHODH (0.74) | PARP1PARP2DHODH | |
| SCHEMBL56853 | 0.67 | PARP1 (0.62) | ATRPARP1DHODHGRIN2B | |
| SCHEMBL25455634 | 0.66 | KDM1A (0.51) | DGAT1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |