Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.43 |
| ▸ | BAD | Q92934 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23112007 | 0.87 | ALDH1A1 (0.55) | STING1KDM4EALDH1A1L3MBTL1GAA | |
| SCHEMBL5331074 | 0.86 | STING1 (0.56) | STING1KDM4EALDH1A1L3MBTL1GAA | |
| SCHEMBL26049804 | 0.84 | EDNRA (0.50) | STING1KDM4EALDH1A1L3MBTL1GAA | |
| SCHEMBL4272799 | 0.77 | MCL1 (0.51) | KDM4EALDH1A1L3MBTL1GAAHPGD | |
| SCHEMBL22909056 | 0.76 | ALDH1A1 (0.55) | KDM4EALDH1A1L3MBTL1GAAHPGD | |
| SCHEMBL10691094 | 0.76 | STING1 (0.55) | STING1KDM4EALDH1A1L3MBTL1GAA | |
| SCHEMBL29513048 | 0.76 | ALDH1A1 (0.55) | KDM4EALDH1A1L3MBTL1GAAHPGD | |
| SCHEMBL22909079 | 0.75 | ALDH1A1 (0.51) | STING1KDM4EALDH1A1L3MBTL1GAA | |
| SCHEMBL22908996 | 0.75 | ALDH1A1 (0.51) | STING1KDM4EALDH1A1L3MBTL1GAA | |
| SCHEMBL30765073 | 0.75 | ALDH1A1 (0.51) | STING1KDM4EALDH1A1L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543584-B1 | Benzo(b)thiophene-2-carboxamides for the treatment of disorders of the central nervous system | LILLY INDUSTRIES LTD (GB) | 1996-05-22 | — | — | EP | disclosed |
| US-5338735-A | For treatment of central nervous system disorders | LILLY INDUSTRIES LIMITED (GB) | 1994-08-16 | — | — | US | disclosed |
| EP-0543584-A1 | Benzo(b)thiophene-2-carboxamides for the treatment of disorders of the central nervous system | LILLY INDUSTRIES LIMITED (GB) | 1993-05-26 | — | — | EP | disclosed |