SCHEMBL9025575

SCHEMBL9025575

O=[N+]([O-])C=C1NCCCC1CCc1ccc(Cl)nc1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNA3 P32297 3/20 0.53
CHRNA1 P02708 1/20 0.53
CHRNA7 P36544 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.50
CHRNB2 P17787 2/20 0.43
CHRNA4 P43681 2/20 0.43
ALDH1A1 P00352 3/20 0.40
PSEN1 P49768 1/20 0.37
PSEN2 P49810 1/20 0.37
APH1B Q8WW43 1/20 0.37
NCSTN Q92542 1/20 0.37
APH1A Q96BI3 1/20 0.37
PSENEN Q9NZ42 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
MAPT P10636 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
RXFP1 Q9HBX9 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7664585 0.93 SMN1; SMN2 (0.52) CHRNA3CHRNA1CHRNA7SMN1; SMN2CHRNB2
SCHEMBL7128344 0.89 CHRNA3 (0.57) CHRNA3CHRNA1CHRNA7SMN1; SMN2CHRNB2
SCHEMBL7122960 0.82 SMN1; SMN2 (0.57) CHRNA3CHRNA1CHRNA7SMN1; SMN2CHRNB2
SCHEMBL9025805 0.79 CHRNA1 (0.35) CHRNA3CHRNA1CHRNA7SMN1; SMN2ALDH1A1
SCHEMBL1747707 0.76 CHRNA3 (0.47) CHRNA3CHRNA1CHRNA7SMN1; SMN2CHRNB2
SCHEMBL12778028 0.76 CHRNA3 (0.47) CHRNA3CHRNA1CHRNA7SMN1; SMN2CHRNB2
SCHEMBL7124862 0.72 CHRNA1 (0.36) CHRNA3CHRNA1CHRNA7SMN1; SMN2ALDH1A1
SCHEMBL7124857 0.72 CHRNA1 (0.36) CHRNA3CHRNA1CHRNA7SMN1; SMN2ALDH1A1
SCHEMBL9026312 0.72 MAPT (0.35) CHRNA3CHRNA1CHRNA7SMN1; SMN2ALDH1A1
SCHEMBL9025632 0.71 PSEN1 (0.43) CHRNA3CHRNA7SMN1; SMN2CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0693066-A1 NOVEL 2-NITROMETHYLIDENE/2-CYANIMINO/2-NITRO-IMINO-PYRROLIDINES AND PIPERIDINES, INTERMEDIATES, AND THEIR USE AS PESTICIDES Novartis AG (CH) 1996-01-24 EP claimed
EP-0693066-A1 NOVEL 2-NITROMETHYLIDENE/2-CYANIMINO/2-NITRO-IMINO-PYRROLIDINES AND PIPERIDINES, INTERMEDIATES, AND THEIR USE AS PESTICIDES Novartis AG (CH) 1996-01-24 EP disclosed