Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 3/20 | 0.57 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.57 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7122960 | 0.93 | SMN1; SMN2 (0.57) | CHRNA3CHRNA1CHRNA7SMN1; SMN2CHRNB2 | |
| SCHEMBL9025575 | 0.89 | CHRNA3 (0.53) | CHRNA3CHRNA1CHRNA7SMN1; SMN2CHRNB2 | |
| SCHEMBL7664585 | 0.82 | SMN1; SMN2 (0.52) | CHRNA3CHRNA1CHRNA7SMN1; SMN2CHRNB2 | |
| SCHEMBL7124862 | 0.78 | CHRNA1 (0.36) | CHRNA3CHRNA1CHRNA7SMN1; SMN2ALDH1A1 | |
| SCHEMBL7124857 | 0.78 | CHRNA1 (0.36) | CHRNA3CHRNA1CHRNA7SMN1; SMN2ALDH1A1 | |
| SCHEMBL1747707 | 0.78 | CHRNA3 (0.47) | CHRNA3CHRNA1CHRNA7SMN1; SMN2CHRNB2 | |
| SCHEMBL12778028 | 0.78 | CHRNA3 (0.47) | CHRNA3CHRNA1CHRNA7SMN1; SMN2CHRNB2 | |
| SCHEMBL7118289 | 0.76 | CHRNA3 (0.50) | CHRNA3CHRNA1CHRNA7SMN1; SMN2CHRNB2 | |
| SCHEMBL17768339 | 0.75 | SMN1; SMN2 (0.55) | CHRNA3CHRNA1CHRNA7SMN1; SMN2CHRNB2 | |
| SCHEMBL7121435 | 0.73 | SMN1; SMN2 (0.52) | CHRNA3CHRNA1CHRNA7SMN1; SMN2CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6664248-B2 | Well tolerated by animals, fish and plants | SYNGENTA INVESTMENT CORP. | 2003-12-16 | — | — | US | claimed |
| US-20030166635-A1 | Novel 2-nitromethylidene/2-cyanimino/2-nitro-imino-pyrrolidines and piperidines, intermediates, and their use as pesticides | MAIENFISCH PETER (CH) | 2003-09-04 | — | — | US | claimed |
| US-20020068733-A1 | Novel 2-nitromethylidene/2-cyanimino/2-nitro-imino-pyrrolidines and piperidines, intermediates, and their use as pesticides | MAIENFISCH PETER (CH) | 2002-06-06 | — | — | US | claimed |
| US-6353001-B1 | PESTICIDES, INSECTICIDES, APHIDICIDES AND LARVICIDES | SYNGENTA INVESTMENT CORPORATION | 2002-03-05 | — | — | US | claimed |
| EP-0693066-B1 | 2-NITROMETHYLIDENE/2-CYANIMINO/2-NITRO-IMINO-PYRROLIDINES AND PIPERIDINES, INTERMEDIATES, AND THEIR USE AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2001-05-16 | — | — | EP | claimed |
| EP-0693066-A1 | NOVEL 2-NITROMETHYLIDENE/2-CYANIMINO/2-NITRO-IMINO-PYRROLIDINES AND PIPERIDINES, INTERMEDIATES, AND THEIR USE AS PESTICIDES | Novartis AG (CH) | 1996-01-24 | — | — | EP | claimed |
| WO-1994024124-A1 | NOVEL 2-NITROMETHYLIDENE/2-CYANIMINO/2-NITRO-IMINO-PYRROLIDINES AND PIPERIDINES, INTERMEDIATES, AND THEIR USE AS PESTICIDES | CIBA-GEIGY AG (CH) | 1994-10-27 | — | — | WO | claimed |
| US-6664248-B2 | Well tolerated by animals, fish and plants | SYNGENTA INVESTMENT CORP. | 2003-12-16 | — | — | US | disclosed |
| US-20030166635-A1 | Novel 2-nitromethylidene/2-cyanimino/2-nitro-imino-pyrrolidines and piperidines, intermediates, and their use as pesticides | MAIENFISCH PETER (CH) | 2003-09-04 | — | — | US | disclosed |
| US-6506743-B2 | Especially for controlling insects. | SYNGENTA INVESTMENT CORPORATION | 2003-01-14 | — | — | US | disclosed |
| US-20020068733-A1 | Novel 2-nitromethylidene/2-cyanimino/2-nitro-imino-pyrrolidines and piperidines, intermediates, and their use as pesticides | MAIENFISCH PETER (CH) | 2002-06-06 | — | — | US | disclosed |
| US-6353001-B1 | PESTICIDES, INSECTICIDES, APHIDICIDES AND LARVICIDES | SYNGENTA INVESTMENT CORPORATION | 2002-03-05 | — | — | US | disclosed |
| EP-0693066-B1 | 2-NITROMETHYLIDENE/2-CYANIMINO/2-NITRO-IMINO-PYRROLIDINES AND PIPERIDINES, INTERMEDIATES, AND THEIR USE AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2001-05-16 | — | — | EP | disclosed |
| US-6048824-A | 2-nitromethylidene/2-cyanimino/2-nitro-imino-pyrrolidines and piperidines, intermediates, and their use as pesticides | NOVARTIS CORPORATION (US) | 2000-04-11 | — | — | US | disclosed |
| EP-0693066-A1 | NOVEL 2-NITROMETHYLIDENE/2-CYANIMINO/2-NITRO-IMINO-PYRROLIDINES AND PIPERIDINES, INTERMEDIATES, AND THEIR USE AS PESTICIDES | Novartis AG (CH) | 1996-01-24 | — | — | EP | disclosed |
| WO-1994024124-A1 | NOVEL 2-NITROMETHYLIDENE/2-CYANIMINO/2-NITRO-IMINO-PYRROLIDINES AND PIPERIDINES, INTERMEDIATES, AND THEIR USE AS PESTICIDES | CIBA-GEIGY AG (CH) | 1994-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068733-A1 | Novel 2-nitromethylidene/2-cyanimino/2-nitro-imino-pyrrolidines and piperidines, intermediates, and their use as pesticides | HCN1, HCN2, CNTN1 | CHRNA3 162/4885CHRNA1 232/4885CHRNA7 285/4885 |
| US-20030166635-A1 | Novel 2-nitromethylidene/2-cyanimino/2-nitro-imino-pyrrolidines and piperidines, intermediates, and their use as pesticides | HCN1, HCN2, CNTN1 | CHRNA3 141/4885CHRNA1 209/4885CHRNA7 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.