Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PAICS | P22234 | 2/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | NEK2 | P51955 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026352 | 0.92 | KDM4E (0.32) | KDM4EL3MBTL1PAICS | |
| SCHEMBL9025304 | 0.88 | KDM4E (0.37) | KDM4EL3MBTL1NEK2MAPTRAD52 | |
| SCHEMBL9025502 | 0.86 | PDE7A (0.37) | KDM4EL3MBTL1PAICSPDE7APDE3A | |
| SCHEMBL9025657 | 0.86 | MAPK14 (0.37) | KDM4EL3MBTL1PAICSMAPTALDH1A1 | |
| Water SCHEMBL9025694 | 0.82 | MEN1 (0.41) | KDM4EALDH1A1LMNA | |
| Water SCHEMBL9025692 | 0.82 | MEN1 (0.41) | KDM4EALDH1A1LMNA | |
| SCHEMBL9025609 | 0.81 | TLR8 (0.44) | — | |
| SCHEMBL9025961 | 0.79 | KDM4E (0.34) | KDM4EL3MBTL1MAPTALDH1A1MAPK1 | |
| SCHEMBL9026614 | 0.77 | SIGMAR1 (0.43) | LMNA | |
| Water SCHEMBL9218005 | 0.77 | HRH3 (0.43) | KDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | claimed |
| EP-0711290-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004052-A1 | METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES | SANOFI (FR) | 1995-02-09 | — | — | WO | disclosed |