Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 4/20 | 0.47 |
| ▸ | RXRA | P19793 | 2/20 | 0.46 |
| ▸ | RXRB | P28702 | 2/20 | 0.46 |
| ▸ | RXRG | P48443 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026424 | 0.91 | PTGS2 (0.47) | PPARDRXRARXRBRXRGPTGS2 | |
| SCHEMBL7497356 | 0.90 | PTGS2 (0.54) | PPARDRXRARXRBRXRGPTGS2 | |
| SCHEMBL7508729 | 0.90 | PTGS2 (0.54) | PPARDRXRARXRBRXRGPTGS2 | |
| SCHEMBL7505609 | 0.89 | PTGS2 (0.58) | PPARDPTGS2PTGS1NR4A2 | |
| SCHEMBL7497858 | 0.89 | PTGS2 (0.58) | PPARDPTGS2PTGS1NR4A2 | |
| SCHEMBL7498789 | 0.89 | PTGS2 (0.56) | PPARDRXRARXRBRXRGPTGS2 | |
| SCHEMBL7502050 | 0.89 | PTGS2 (0.56) | PPARDRXRARXRBRXRGPTGS2 | |
| SCHEMBL7505683 | 0.88 | PTGS2 (0.59) | PPARDPTGS2PTGS1 | |
| SCHEMBL9026427 | 0.86 | PTGS2 (0.43) | PPARDRXRAPTGS2PTGS1CYP1A2 | |
| SCHEMBL7506460 | 0.85 | PTGS2 (0.62) | PPARDPTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |