Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 6/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026297 | 0.88 | PTGS2 (0.53) | PTGS2PTGS1NR1H4NR4A2RXRA | |
| SCHEMBL9026424 | 0.87 | PTGS2 (0.47) | PTGS2PTGS1PPARDNR4A2RXRA | |
| SCHEMBL7497356 | 0.87 | PTGS2 (0.54) | PTGS2PTGS1PPARDNR1H4NR4A2 | |
| SCHEMBL7508729 | 0.87 | PTGS2 (0.54) | PTGS2PTGS1PPARDNR1H4NR4A2 | |
| SCHEMBL9026334 | 0.86 | PPARD (0.47) | PTGS2PTGS1PPARDNR1H4NR4A2 | |
| SCHEMBL7505609 | 0.85 | PTGS2 (0.58) | PTGS2PTGS1PPARDNR4A2 | |
| SCHEMBL7497858 | 0.85 | PTGS2 (0.58) | PTGS2PTGS1PPARDNR4A2 | |
| SCHEMBL7505683 | 0.82 | PTGS2 (0.59) | PTGS2PTGS1PPARD | |
| SCHEMBL7506460 | 0.81 | PTGS2 (0.62) | PTGS2PTGS1PPARD | |
| SCHEMBL9037840 | 0.80 | CA1 (0.44) | PTGS2PTGS1NR4A2RXRACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |