Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | IAPP | P10997 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | CTSG | P08311 | 1/20 | 0.37 |
| ▸ | BID | P55957 | 3/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.36 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.36 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11814659 | 0.90 | BID (0.44) | MTNR1AGABRA1GABRB2IAPPELANE | |
| SCHEMBL84570 | 0.89 | BID (0.50) | MTNR1ABIDMCL1BCL2L1BAK1 | |
| Propylene Oxide SCHEMBL29248582 | 0.89 | MTNR1A (0.40) | MTNR1AGABRA1GABRB2AKR1B1IAPP | |
| SCHEMBL8518967 | 0.87 | BID (0.52) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL8583416 | 0.87 | BID (0.52) | BIDMCL1BCL2L1BAK1KAT8 | |
| Hydrogen Sulfide SCHEMBL5261196 | 0.87 | BID (0.49) | MTNR1ABIDMCL1BCL2L1BAK1 | |
| SCHEMBL12802066 | 0.87 | GABRA1 (0.42) | MTNR1AGABRA1GABRB2AKR1B1MEN1 | |
| SCHEMBL28738149 | 0.86 | MTNR1A (0.48) | MTNR1AGABRA1GABRB2AKR1B1IAPP | |
| SCHEMBL254084 | 0.83 | GABRA1 (0.57) | MTNR1AGABRA1GABRB2AKR1B1SRD5A1 | |
| SCHEMBL27372200 | 0.83 | IAPP (0.41) | MTNR1AGABRA1GABRB2IAPPHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |