Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 15/20 | 0.91 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.45 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704120 | 0.95 | KARS1 (1.00) | KARS1AURKARIPK1PRKD1PRKD2 | |
| SCHEMBL10267664 | 0.92 | KARS1 (0.77) | KARS1PRKD1PRKD2 | |
| SCHEMBL1704560 | 0.91 | KARS1 (0.74) | KARS1PRKD1PRKD2 | |
| SCHEMBL902773 | 0.90 | KARS1 (1.00) | KARS1KDM4E | |
| SCHEMBL901349 | 0.89 | KARS1 (0.80) | KARS1PRKD1PRKD2 | |
| SCHEMBL901889 | 0.87 | KARS1 (0.81) | KARS1PRKD1PRKD2 | |
| SCHEMBL901191 | 0.86 | KARS1 (0.70) | KARS1PRKD1PRKD2 | |
| SCHEMBL901763 | 0.85 | KARS1 (1.00) | KARS1PRKD1PRKD2 | |
| SCHEMBL901620 | 0.84 | KARS1 (1.00) | KARS1PRKD1PRKD2GSK3BDYRK1A | |
| SCHEMBL1755644 | 0.84 | KARS1 (0.76) | KARS1PRKD1PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |