Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 14/20 | 1.00 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704120 | 0.93 | KARS1 (1.00) | KARS1KDM4E | |
| SCHEMBL1704905 | 0.91 | KARS1 (0.83) | KARS1MAPK8MAPK10RXFP1KDM4E | |
| SCHEMBL902767 | 0.90 | KARS1 (0.91) | KARS1KDM4E | |
| SCHEMBL901889 | 0.88 | KARS1 (0.81) | KARS1 | |
| SCHEMBL1705200 | 0.88 | KARS1 (0.78) | KARS1MAPK8MAPK10RXFP1KDM4E | |
| SCHEMBL1704902 | 0.84 | KARS1 (0.73) | KARS1KDM4ETP53MEN1KMT2A | |
| SCHEMBL901349 | 0.84 | KARS1 (0.80) | KARS1 | |
| SCHEMBL1755684 | 0.84 | KARS1 (0.78) | KARS1 | |
| SCHEMBL10267664 | 0.82 | KARS1 (0.77) | KARS1 | |
| SCHEMBL902572 | 0.82 | KARS1 (0.69) | KARS1KDM4ETP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |