Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028319 | 0.79 | — | — | |
| SCHEMBL9027689 | 0.77 | KDM4E (0.36) | MEN1KMT2AKDM4ESRD5A1 | |
| SCHEMBL9027770 | 0.76 | MEN1 (0.33) | MEN1KMT2AKDM4ESRD5A1PDE4A | |
| SCHEMBL9028097 | 0.76 | MAOB (0.36) | — | |
| SCHEMBL9028180 | 0.75 | MEN1 (0.33) | MEN1KMT2AKDM4ESRD5A1PDE4A | |
| SCHEMBL9028192 | 0.69 | KDM4E (0.37) | MEN1KMT2AKDM4ESRD5A1 | |
| SCHEMBL6766966 | 0.68 | ALDH1A1 (0.33) | KDM4ETP53CYP3A4 | |
| SCHEMBL9028221 | 0.67 | FFAR4 (0.33) | — | |
| SCHEMBL9571427 | 0.65 | ALDH1A1 (0.31) | MEN1KMT2A | |
| SCHEMBL9571516 | 0.65 | EZH2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |