Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | OSBP | P22059 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | AKT1 | P31749 | 2/20 | 0.30 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | PHLPP1 | O60346 | 1/20 | 0.30 |
| ▸ | ILK | Q13418 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028612 | 0.79 | HTR2A (0.34) | HTR2AOSBPPOLB | |
| SCHEMBL9028225 | 0.79 | DHFR (0.38) | HTR2ADHFROSBPPOLB | |
| SCHEMBL9722345 | 0.77 | POLB (0.33) | POLB | |
| SCHEMBL9027394 | 0.76 | CYP26A1 (0.36) | — | |
| SCHEMBL9028319 | 0.76 | — | — | |
| SCHEMBL9028068 | 0.75 | MAOB (0.38) | — | |
| SCHEMBL9571516 | 0.69 | EZH2 (0.31) | POLB | |
| SCHEMBL9571543 | 0.67 | LMNA (0.32) | HTR2APOLB | |
| SCHEMBL9571427 | 0.67 | ALDH1A1 (0.31) | POLB | |
| SCHEMBL14283919 | 0.66 | AKT1 (0.46) | HTR2ADHFRAKT1PDPK1PHLPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |