Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.34 |
| ▸ | HMGCR | P04035 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028606 | 0.79 | HTT (0.41) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL9028203 | 0.75 | HTT (0.41) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL9028435 | 0.73 | DHFR (0.37) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL9029571 | 0.72 | HTT (0.53) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL9027854 | 0.72 | CA1 (0.38) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL5677726 | 0.72 | HMGCR (0.40) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL5532933 | 0.71 | HMGCR (0.42) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL1760617 | 0.71 | HMGCR (0.42) | HTTNPC1HPGDMAPK1RAB9A | |
| SCHEMBL27887691 | 0.70 | HMGCR (0.45) | HTTMAPK1PRKCIHMGCRALOX5 | |
| SCHEMBL5919979 | 0.70 | HMGCR (0.39) | HTTNPC1HPGDMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4356435-A | — | — | None | — | — | JP | disclosed |
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| JP-H04356435-A | PROPENE DERIBATIVE | FUJIREBIO INC | 1992-12-10 | — | — | JP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |