Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 7/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028667 | 0.85 | MAOB (0.37) | MAOBGAANPC1RAB9ABCHE | |
| SCHEMBL9029056 | 0.84 | LTA4H (0.38) | MAOBGAANPC1RAB9ABCHE | |
| SCHEMBL9029180 | 0.81 | MAOB (0.38) | MAOBL3MBTL1GAAALDH1A1MAPT | |
| SCHEMBL9028070 | 0.80 | NPC1 (0.38) | MAOBL3MBTL1GAAALDH1A1MAPT | |
| SCHEMBL9028802 | 0.80 | MAOB (0.36) | MAOBGAAALDH1A1NPC1RAB9A | |
| SCHEMBL9028973 | 0.80 | MAOB (0.36) | MAOBL3MBTL1GAAALDH1A1MAPT | |
| SCHEMBL9028097 | 0.79 | MAOB (0.36) | MAOBL3MBTL1GAAALDH1A1MAPT | |
| SCHEMBL9028073 | 0.78 | MAOB (0.35) | MAOBL3MBTL1GAAALDH1A1MAPT | |
| SCHEMBL9028219 | 0.78 | MAOB (0.36) | MAOBGAAALDH1A1NPC1RAB9A | |
| SCHEMBL9028554 | 0.78 | MAOB (0.34) | MAOBL3MBTL1GAAALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |