Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028192 | 0.76 | KDM4E (0.37) | KDM4EMEN1KMT2ASRD5A1PTGS1 | |
| SCHEMBL9027859 | 0.73 | KDM4E (0.35) | KDM4EMEN1KMT2ASRD5A1 | |
| SCHEMBL9028266 | 0.71 | KDM4E (0.36) | KDM4EMEN1KMT2APTGS1 | |
| SCHEMBL17612610 | 0.70 | KDM4E (0.43) | KDM4EMEN1KMT2ASRD5A1PTGS1 | |
| SCHEMBL9027689 | 0.69 | KDM4E (0.36) | KDM4EMEN1KMT2ASRD5A1 | |
| SCHEMBL9028435 | 0.69 | DHFR (0.37) | KDM4EMEN1KMT2A | |
| SCHEMBL9028140 | 0.69 | KDM4E (0.38) | KDM4EMEN1KMT2A | |
| SCHEMBL11890175 | 0.68 | PTGS1 (0.44) | KDM4EMEN1KMT2ASRD5A1PTGS1 | |
| SCHEMBL8603161 | 0.67 | KDM4E (0.42) | KDM4EMEN1KMT2ASRD5A1PTGS1 | |
| SCHEMBL11890176 | 0.67 | SRD5A1 (0.47) | KDM4EMEN1KMT2ASRD5A1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |