Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028255 | 0.74 | CYP1A2 (0.35) | KDM4EALDH1A1HPGDKMT2AGAA | |
| SCHEMBL9027573 | 0.73 | KDM4E (0.34) | KDM4EALDH1A1HPGDGAATSHR | |
| SCHEMBL9028420 | 0.72 | LTB4R (0.39) | KDM4EALDH1A1HPGDTSHRNPC1 | |
| SCHEMBL9028196 | 0.71 | KDM4E (0.39) | KDM4EMEN1KMT2APTGS1 | |
| SCHEMBL11890175 | 0.70 | PTGS1 (0.44) | KDM4EALOX5MEN1KMT2APTGS1 | |
| SCHEMBL9028786 | 0.70 | ALOX5 (0.37) | KDM4EALOX5ALDH1A1HPGDMEN1 | |
| SCHEMBL8600805 | 0.68 | HTT (0.44) | KDM4EALDH1A1HPGDGAATSHR | |
| SCHEMBL9028753 | 0.67 | ALOX5 (0.47) | KDM4EALOX5ALDH1A1HPGDMEN1 | |
| SCHEMBL9027559 | 0.67 | LTA4H (0.40) | KDM4EALOX5ALDH1A1MEN1KMT2A | |
| SCHEMBL11891655 | 0.67 | ALOX5 (0.48) | KDM4EALOX5ALDH1A1GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |