Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 19/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9029548 | 0.86 | ALOX5 (0.63) | ALOX5 | |
| SCHEMBL9367498 | 0.85 | ALOX5 (0.66) | ALOX5 | |
| SCHEMBL9026717 | 0.84 | ALOX5 (0.54) | ALOX5 | |
| SCHEMBL9026909 | 0.84 | ALOX5 (0.53) | ALOX5 | |
| SCHEMBL9371367 | 0.82 | ALOX5 (0.56) | ALOX5 | |
| SCHEMBL9027549 | 0.80 | ALOX5 (0.52) | ALOX5MEN1KMT2A | |
| SCHEMBL9098781 | 0.79 | ALOX5 (0.56) | ALOX5 | |
| SCHEMBL9440429 | 0.78 | ALOX5 (0.44) | ALOX5 | |
| SCHEMBL9384495 | 0.78 | ALOX5 (0.44) | ALOX5 | |
| SCHEMBL9380811 | 0.78 | ALOX5 (0.61) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462831-B1 | Bicyclic pyran derivatives and their use as inhibitors of 5-lipoxygenase | ZENECA LTD (GB) | 1996-02-28 | — | — | EP | claimed |
| US-5179115-A | Antiinflammatory agents, antiallergens | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-01-12 | — | — | US | claimed |
| JP-4243865-A | — | — | None | — | — | JP | disclosed |
| EP-0462831-B1 | Bicyclic pyran derivatives and their use as inhibitors of 5-lipoxygenase | ZENECA LTD (GB) | 1996-02-28 | — | — | EP | disclosed |
| US-5462953-A | Benzoxazolyl derivatives useful as 5-lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-10-31 | — | — | US | disclosed |
| US-5364877-A | Antiinflammatory agents, antiallergens | ICI PHARMA (GB) | 1994-11-15 | — | — | US | disclosed |
| US-5278177-A | Enzyme inhibitory | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-01-11 | — | — | US | disclosed |
| US-5179115-A | Antiinflammatory agents, antiallergens | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-01-12 | — | — | US | disclosed |
| JP-H04243865-A | BICYCLIC HETEROCYCLIC DERIVATIVE, ITS PRODUCTION AND PHARMACEUTICAL COMPOSITE FOR TREATMENT OF LEUKOTRIENE INTERMEDIATED DISEASE OR MEDICAL ABNORMALITY | ICI PHARMA | 1992-08-31 | — | — | JP | disclosed |
| EP-0462831-A2 | Bicyclic pyran derivatives and their use as inhibitors of 5-lipoxygenase | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | disclosed |