Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | HPD | P32754 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9027439 | 0.90 | MAOB (0.41) | LMNAGAANPC1RAB9AMAPT | |
| SCHEMBL9028477 | 0.89 | CDK4 (0.40) | LMNAGAAPSEN1MAPTL3MBTL1 | |
| SCHEMBL9028469 | 0.89 | CDK4 (0.40) | LMNAGAAPSEN1MAPTL3MBTL1 | |
| SCHEMBL8308667 | 0.86 | PSEN1 (0.45) | LMNAGAAPSEN1MAPTL3MBTL1 | |
| SCHEMBL9028428 | 0.84 | LMNA (0.33) | LMNAGAAPSEN1MAPTL3MBTL1 | |
| SCHEMBL9028421 | 0.84 | LMNA (0.33) | LMNAGAAPSEN1MAPTL3MBTL1 | |
| SCHEMBL9028981 | 0.83 | PSEN1 (0.34) | LMNAGAAPSEN1MAPTL3MBTL1 | |
| SCHEMBL5957804 | 0.82 | PSEN1 (0.40) | LMNAGAAPSEN1HPGDMAOB | |
| SCHEMBL9028395 | 0.81 | MAOB (0.38) | LMNAGAANPC1RAB9AMAPT | |
| SCHEMBL9028284 | 0.80 | MAOB (0.34) | LMNAGAAPSEN1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |