Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 3/20 | 0.40 |
| ▸ | CCND1 | P24385 | 3/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | HPD | P32754 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028469 | 1.00 | CDK4 (0.40) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL9029017 | 0.91 | CDK4 (0.41) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL9029023 | 0.91 | CDK4 (0.41) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL9028233 | 0.89 | LMNA (0.36) | LMNAGAAPSEN1MAOBHPGD | |
| SCHEMBL9028428 | 0.84 | LMNA (0.33) | LMNAGAAPSEN1MAOBHPGD | |
| SCHEMBL9028421 | 0.84 | LMNA (0.33) | LMNAGAAPSEN1MAOBHPGD | |
| SCHEMBL8308667 | 0.82 | PSEN1 (0.45) | LMNAGAAPSEN1MAOBHPGD | |
| SCHEMBL9027439 | 0.79 | MAOB (0.41) | LMNAGAAMAOBHPGDHPD | |
| SCHEMBL9028981 | 0.79 | PSEN1 (0.34) | LMNAGAAPSEN1MAOBHPGD | |
| SCHEMBL5957804 | 0.78 | PSEN1 (0.40) | LMNAGAAPSEN1MAOBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |