Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5706719 | 0.83 | CYP1A2 (0.52) | CYP2C9CYP2C19CYP1A2CA2CA1 | |
| SCHEMBL29005805 | 0.79 | CYP1A2 (0.47) | CYP2C9CYP2C19CYP1A2CA2CA1 | |
| SCHEMBL29602988 | 0.79 | CYP1A2 (0.47) | CYP2C9CYP2C19CYP1A2CA2CA1 | |
| SCHEMBL10954074 | 0.78 | CA2 (0.77) | CYP2C9CYP2C19CYP1A2CA2CA1 | |
| SCHEMBL9028543 | 0.78 | KDM4E (0.38) | SMN1; SMN2ALDH1A1POLBMAPTHTT | |
| SCHEMBL28526351 | 0.76 | NR1H4 (0.59) | CYP2C9CYP2C19CYP1A2CA2CA1 | |
| SCHEMBL8985728 | 0.76 | CYP1A2 (0.47) | CYP2C9CYP2C19CYP1A2CA2CA1 | |
| SCHEMBL29732475 | 0.76 | CYP1A2 (0.47) | CYP2C9CYP2C19CYP1A2CA2CA1 | |
| SCHEMBL716507 | 0.76 | CYP1A2 (0.47) | CYP2C9CYP2C19CYP1A2CA2CA1 | |
| SCHEMBL7525739 | 0.75 | VCAM1 (0.40) | CA2CA1SMN1; SMN2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |