SCHEMBL9028374

SCHEMBL9028374

COc1cc(C(=O)N2CC(O)CC2C(=O)O)cc(OC)c1OC

nearest known ligand 0.56

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 3/20 0.56
ANPEP P15144 3/20 0.56
ALDH1A1 P00352 2/20 0.48
CYP1A2 P05177 1/20 0.48
ATM Q13315 1/20 0.48
GAA P10253 1/20 0.46
POLB P06746 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.44
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9029658 1.00 MMP2 (0.56) MMP2ANPEPALDH1A1CYP1A2ATM
SCHEMBL9028971 0.88 GAA (0.45) MMP2ANPEPALDH1A1CYP1A2GAA
SCHEMBL9308374 0.88 MMP2 (0.58) MMP2ANPEPALDH1A1CYP1A2GAA
SCHEMBL19505987 0.88 MMP2 (0.58) MMP2ANPEPALDH1A1CYP1A2GAA
SCHEMBL9310068 0.86 MMP2 (0.50) MMP2ANPEPALDH1A1CYP1A2ATM
SCHEMBL9029677 0.86 MMP2 (0.50) MMP2ANPEPALDH1A1CYP1A2ATM
SCHEMBL9310050 0.86 MMP2 (0.50) MMP2ANPEPALDH1A1CYP1A2ATM
SCHEMBL9027917 0.84 MEN1 (0.48) MMP2ANPEPALDH1A1KMT2A
SCHEMBL9027922 0.84 MEN1 (0.48) MMP2ANPEPALDH1A1KMT2A
SCHEMBL9028379 0.82 ALDH1A1 (0.46) MMP2ANPEPALDH1A1CYP1A2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0486386-B1 Novel derivatives of N-benzoylproline, process for their preparation and drugs containing them ADIR (FR) 1996-07-17 EP claimed
US-5332735-A Antiamnesic activity ADIR ET COMPAGNIE (FR) 1994-07-26 US claimed
EP-0486386-A2 Novel derivatives of N-benzoylproline, process for their preparation and drugs containing them ADIR ET COMPAGNIE (FR) 1992-05-20 EP claimed
EP-0486386-B1 Novel derivatives of N-benzoylproline, process for their preparation and drugs containing them ADIR (FR) 1996-07-17 EP disclosed
US-5332735-A Antiamnesic activity ADIR ET COMPAGNIE (FR) 1994-07-26 US disclosed
EP-0486386-A2 Novel derivatives of N-benzoylproline, process for their preparation and drugs containing them ADIR ET COMPAGNIE (FR) 1992-05-20 EP disclosed