SCHEMBL9028773

SCHEMBL9028773

COC=CC(=O)O.Cc1ccccc1C=C(F)c1nc(-c2ccc(OC(F)(F)F)cc2)no1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SCN10A Q9Y5Y9 1/20 0.47
IP6K1 Q92551 1/20 0.39
IP6K3 Q96PC2 1/20 0.39
IP6K2 Q9UHH9 1/20 0.39
DPP4 P27487 1/20 0.39
DPP7 Q9UHL4 1/20 0.39
CASP3 P42574 1/20 0.37
S1PR1 P21453 3/20 0.36
MAPT P10636 3/20 0.35
PKM P14618 1/20 0.35
XBP1 P17861 1/20 0.35
LMNA P02545 1/20 0.35
HDAC1 Q13547 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
TRPV1 Q8NER1 1/20 0.34
LIPE Q05469 1/20 0.34
IDH1 O75874 2/20 0.34
NR1H4 Q96RI1 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9027887 0.90 MAPT (0.40) S1PR1MAPTLMNANR1H4
SCHEMBL9028408 0.89 SCN10A (0.48) SCN10AIP6K1IP6K3IP6K2DPP4
SCHEMBL9027944 0.78 NPC1 (0.39) S1PR1MAPTLMNANR1H4
SCHEMBL9027869 0.77 SCN10A (0.47) SCN10ADPP4DPP7CASP3S1PR1
SCHEMBL15491561 0.72 SCN10A (0.62) SCN10AIP6K1IP6K3IP6K2DPP4
SCHEMBL15489376 0.71 SCN10A (0.64) SCN10ADPP4DPP7CASP3S1PR1
SCHEMBL9401168 0.70 GAA (0.44) LMNA
SCHEMBL15486814 0.69 HTT (0.62) SCN10ADPP4DPP7CASP3S1PR1
SCHEMBL9401102 0.69 MAPT (0.46) CASP3MAPT
SCHEMBL9401109 0.69 ALDH1A1 (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0544587-B1 Alpha-methylene-2-vinyl-benzeneacetic acid derivatives, process for their preparation and their use as pesticides ROUSSEL UCLAF (FR) 1996-05-29 EP claimed
US-5310746-A Insecticides, miticides, nematocides ROUSSEL UCLAF (FR) 1994-05-10 US disclosed