Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.53 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.53 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.53 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | RAD52 | P43351 | 2/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CASP2 | P42575 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.55 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | APAF1 | O14727 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9029591 | 0.97 | KDM4E (0.83) | KDM4ERAD52HSP90AA1SMN1; SMN2KMT2A | |
| SCHEMBL29099370 | 0.91 | KDM4E (0.72) | KDM4ERAD52HSP90AA1SMN1; SMN2HTT | |
| SCHEMBL21456850 | 0.83 | KDM4E (0.66) | KDM4ERAD52HSP90AA1SMN1; SMN2HTT | |
| Cetylpyridinium SCHEMBL28164734 | 0.83 | KMT2A (0.72) | KDM4ERAD52HSP90AA1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL23004283 | 0.82 | HTT (0.63) | KDM4ERAD52HSP90AA1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL2760949 | 0.82 | HTT (0.63) | KDM4ERAD52HSP90AA1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL330507 | 0.82 | HTT (0.63) | KDM4ERAD52HSP90AA1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL7613954 | 0.82 | HTT (0.63) | KDM4ERAD52HSP90AA1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL30980158 | 0.82 | HTT (0.63) | KDM4ERAD52HSP90AA1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL330070 | 0.82 | HTT (0.63) | KDM4ERAD52HSP90AA1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277270-B1 | N-alkylated quaternary nitrogen-containing heterocycles, process for their preparation and their use in pharmaceutical compositions | PUETTER MEDICE CHEM PHARM (DE) | 1996-12-27 | — | — | EP | disclosed |
| EP-0207411-B1 | 0-SUBSTITUTED 3-OXY-PYRIDINIUM SALTS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS FUNGICIDES IN CROP PROTECTION | BASF Aktiengesellschaft (DE) | 1989-01-18 | — | — | EP | disclosed |