Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CNR1 | P21554 | 4/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.54 |
| ▸ | CNR2 | P34972 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30421188 | 1.00 | LMNA (0.64) | LMNAKDM4ECNR1CHRM1CNR2 | |
| SCHEMBL29576532 | 0.91 | CNR1 (0.66) | LMNAKDM4ECNR1CNR2 | |
| SCHEMBL21176865 | 0.91 | CNR1 (0.66) | LMNAKDM4ECNR1CNR2 | |
| SCHEMBL7291968 | 0.90 | CNR1 (0.62) | LMNACNR1CNR2 | |
| SCHEMBL24437217 | 0.84 | CNR1 (0.66) | CNR1CNR2 | |
| SCHEMBL3105128 | 0.83 | CNR1 (0.72) | KDM4ECNR1CNR2 | |
| SCHEMBL4142276 | 0.82 | KDM4E (0.47) | LMNAKDM4ECNR1CNR2 | |
| SCHEMBL7291403 | 0.81 | CNR1 (0.60) | CNR1CNR2 | |
| SCHEMBL7914466 | 0.81 | LMNA (0.73) | LMNAKDM4ECHRM1CNR2 | |
| SCHEMBL22416268 | 0.80 | CNR1 (0.74) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0494978-B1 | HETEROCYCLIC COMPOUNDS | WYETH JOHN & BROTHER LTD (GB) | 1996-02-28 | — | — | EP | disclosed |
| US-5362734-A | Certain benzo-quinolizine compounds and derivatives thereof | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-11-08 | — | — | US | disclosed |
| US-5225419-A | Antagonist 5-hydroxytryptamine for treatment of nausea or vomiting | JOHN WYETH & BROTHER, LIMITED (GB) | 1993-07-06 | — | — | US | disclosed |
| US-5096901-A | PHARMACOLOGICALLY ACTIVE AMIDES AND ESTERS CONTAINING AN AZABICYCLOALKANE MOIETY | JOHN WYETH & BROTHER LIMITED (GB) | 1992-03-17 | — | — | US | disclosed |