Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9622079 | 0.84 | LMNA (0.52) | KDM4ETSHRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9121600 | 0.83 | KDM4E (0.55) | KDM4ETSHRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9122374 | 0.81 | KDM4E (0.49) | KDM4ETSHRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9122369 | 0.81 | KDM4E (0.49) | KDM4ETSHRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL5517321 | 0.80 | LMNA (0.63) | KDM4ETSHRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL12035988 | 0.79 | RAB9A (0.51) | KDM4ETSHRALDH1A1MEN1KMT2A | |
| SCHEMBL6474592 | 0.79 | KDM4E (0.57) | KDM4ETSHRLMNAALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5763332 | 0.79 | FFAR1 (0.61) | KDM4ETSHRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL4854282 | 0.79 | KDM4E (0.53) | KDM4ETSHRLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL5763328 | 0.79 | KDM4E (0.53) | KDM4ETSHRLMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |