Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 5/20 | 0.57 |
| ▸ | PPARG | P37231 | 3/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | PTGIR | P43119 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22703735 | 0.84 | PPARA (0.61) | PPARAPPARGALOX5PTGIRCYP2D6 | |
| SCHEMBL10256292 | 0.83 | TSHR (0.48) | PPARAPPARGCYP4F2CYP4A11MEN1 | |
| SCHEMBL9622079 | 0.82 | LMNA (0.52) | PPARAPPARGMTNR1AMTNR1BMEN1 | |
| SCHEMBL10265691 | 0.82 | PPARA (0.44) | PPARAPPARGCYP4F2CYP4A11MEN1 | |
| SCHEMBL10256572 | 0.81 | IDO1 (0.44) | PPARAPPARGCYP4F2CYP4A11MEN1 | |
| SCHEMBL4661089 | 0.80 | ALDH1A1 (0.51) | MEN1ALDH1A1POLBPKMKMT2A | |
| SCHEMBL5169461 | 0.80 | PPARA (0.48) | PPARAPPARGALOX5CYP4F2CYP4A11 | |
| SCHEMBL427612 | 0.79 | CHRM2 (0.58) | PPARAPPARGCYP4F2CYP4A11CYP2D6 | |
| SCHEMBL765936 | 0.78 | PPARA (0.61) | PPARAPPARGCYP2D6MEN1ALDH1A1 | |
| SCHEMBL9028103 | 0.77 | MEN1 (0.35) | PPARAPPARGCYP2D6CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |