Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HMGCR | P04035 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARD | Q03181 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | PPID | Q08752 | 1/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028889 | 0.94 | MMP12 (0.33) | MMP12NPC1RAB9AALDH1A1HMGCR | |
| SCHEMBL9028088 | 0.89 | MMP12 (0.34) | MMP12NPC1RAB9AALDH1A1HMGCR | |
| SCHEMBL9029035 | 0.87 | MMP12 (0.33) | MMP12NPC1RAB9AALDH1A1HMGCR | |
| SCHEMBL9028883 | 0.86 | MMP12 (0.32) | MMP12NPC1RAB9AALDH1A1HMGCR | |
| SCHEMBL9028495 | 0.86 | MMP12 (0.32) | MMP12NPC1RAB9AALDH1A1HMGCR | |
| SCHEMBL9027939 | 0.85 | HMGCR (0.32) | MMP12NPC1RAB9AALDH1A1HMGCR | |
| SCHEMBL9027463 | 0.85 | HMGCR (0.38) | MMP12NPC1RAB9AHMGCRLMNA | |
| SCHEMBL9029391 | 0.83 | PPARG (0.34) | MMP12HMGCRLMNAL3MBTL1PPARG | |
| SCHEMBL9029056 | 0.78 | LTA4H (0.38) | NPC1RAB9ALMNAHTTMAOB | |
| SCHEMBL9027455 | 0.78 | NPC1 (0.37) | MMP12NPC1RAB9AHMGCRPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |