Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | CD74 | P04233 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL649075 | 0.88 | ALDH1A1 (0.46) | TSHRLTA4HALDH1A1HRH3HRH4 | |
| SCHEMBL9078573 | 0.86 | HSP90AB1 (0.41) | L3MBTL1NPC1RAB9ASMN1; SMN2HTR2B | |
| SCHEMBL9024323 | 0.84 | MAOB (0.43) | LTA4HHPGDKDM4E | |
| SCHEMBL9033928 | 0.82 | SMN1; SMN2 (0.38) | L3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9028085 | 0.81 | KMT2A (0.55) | TSHRALDH1A1HPGDL3MBTL1NPC1 | |
| SCHEMBL9023589 | 0.81 | L3MBTL1 (0.59) | TSHRALDH1A1L3MBTL1 | |
| SCHEMBL2104702 | 0.79 | DPYD (0.51) | ALDH1A1L3MBTL1RAB9AKDM4E | |
| SCHEMBL6967970 | 0.79 | ALDH1A1 (0.39) | ALDH1A1HRH3HRH4L3MBTL1RAB9A | |
| SCHEMBL6967651 | 0.79 | KMT2A (0.56) | TSHRALDH1A1HPGDL3MBTL1NPC1 | |
| Proxyfan SCHEMBL4072620 | 0.78 | HRH3 (0.54) | TSHRLTA4HALDH1A1HRH3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5578616-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, TREATMENT FOR GASTROINTESTINAL AND CARDIOVASCULAR DISORDERS | SCHERING CORPORATION (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0729459-A1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014007-A1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 1995-05-26 | — | — | WO | disclosed |