Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | F7 | P08709 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028811 | 0.85 | DDAH1 (0.33) | NPC1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL9029139 | 0.74 | NISCH (0.54) | — | |
| SCHEMBL9024370 | 0.74 | NPC1 (0.34) | NPC1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1627638 | 0.73 | NISCH (0.37) | LMNA | |
| SCHEMBL9040777 | 0.72 | NISCH (0.47) | GAA | |
| SCHEMBL9112216 | 0.72 | NPC1 (0.33) | NPC1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL14854508 | 0.71 | PRMT1 (0.41) | NPC1MAPTRAB9A | |
| SCHEMBL9111634 | 0.71 | NISCH (0.48) | GAA | |
| SCHEMBL9112379 | 0.71 | TOP2A (0.49) | NPC1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL9028183 | 0.71 | TOP2A (0.49) | NPC1LMNAMAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720603-A1 | BIS(AMIDINOBENZIMIDAZOLYL)ALKANES AS ANTIVIRAL AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995008540-A1 | BIS(AMIDINOBENZIMIDAZOLYL)ALKANES AS ANTIVIRAL AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-03-30 | — | — | WO | disclosed |