Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 10/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.70 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.70 |
| ▸ | DRD4 | P21917 | 3/20 | 0.54 |
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
| ▸ | DRD3 | P35462 | 3/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.54 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847623 | 0.82 | OPRL1 (1.00) | OPRL1OPRM1OPRD1OPRK1DRD4 | |
| SCHEMBL5556912 | 0.81 | OPRL1 (0.60) | OPRL1OPRM1OPRD1OPRK1DRD4 | |
| SCHEMBL8894175 | 0.80 | OPRL1 (0.84) | OPRL1OPRM1OPRD1OPRK1DRD4 | |
| SCHEMBL21634300 | 0.78 | OPRL1 (0.86) | OPRL1OPRM1OPRD1OPRK1DRD4 | |
| SCHEMBL20187187 | 0.77 | OPRL1 (0.72) | OPRL1OPRM1OPRD1OPRK1DRD4 | |
| SCHEMBL20187097 | 0.77 | OPRM1 (0.84) | OPRL1OPRM1OPRD1OPRK1DRD4 | |
| SCHEMBL16876775 | 0.77 | OPRL1 (0.84) | OPRL1OPRM1OPRD1OPRK1DRD4 | |
| SCHEMBL6012726 | 0.77 | CXCR3 (0.59) | OPRL1OPRM1OPRD1OPRK1CCR5 | |
| SCHEMBL16876793 | 0.77 | OPRL1 (0.84) | OPRL1OPRM1OPRD1OPRK1DRD4 | |
| SCHEMBL7846905 | 0.77 | OPRL1 (0.84) | OPRL1OPRM1OPRD1OPRK1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745082-A1 | SUBSTITUTED 1,3,8-TRIAZA-SPIRO(4,5)-DECAN-4-ONE DERIVATIVES USEFUL AS PRELIMINARY STAGES IN THE PRODUCTION OF PHARMACEUTICALS | CIS BIO INTERNATIONAL (FR) | 1996-12-04 | — | — | EP | disclosed |
| WO-1995022544-A2 | SUBSTITUTED 1,3,8-TRIAZA-SPIRO(4,5)-DECAN-4-ONE DERIVATIVES USEFUL AS PRELIMINARY STAGES IN THE PRODUCTION OF PHARMACEUTICALS | CIS BIO INTERNATIONAL (FR) | 1995-08-24 | — | — | WO | disclosed |