Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704868 | 0.92 | KARS1 (0.55) | KARS1SYKCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1704347 | 0.88 | KARS1 (0.66) | KARS1 | |
| SCHEMBL1704582 | 0.86 | KARS1 (0.53) | KARS1ACHESYKWNT3ACCNT1 | |
| SCHEMBL1704481 | 0.86 | KARS1 (0.55) | KARS1ACHESYKWNT3A | |
| SCHEMBL1704910 | 0.84 | KARS1 (0.55) | KARS1SYKWNT3A | |
| SCHEMBL901865 | 0.84 | KARS1 (0.54) | KARS1ACHESYKWNT3A | |
| SCHEMBL1704770 | 0.83 | KARS1 (0.59) | KARS1ACHESYKWNT3A | |
| SCHEMBL1704514 | 0.83 | KARS1 (0.54) | KARS1SYKWNT3A | |
| SCHEMBL1704353 | 0.83 | KARS1 (0.55) | KARS1ACHESYKWNT3A | |
| SCHEMBL1704577 | 0.83 | KARS1 (0.56) | KARS1ACHESYKWNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |