Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704347 | 0.92 | KARS1 (0.66) | KARS1 | |
| SCHEMBL902958 | 0.92 | KARS1 (0.51) | KARS1CYP3A4CYP2D6CYP2C9GRIN2B | |
| SCHEMBL901431 | 0.83 | KARS1 (0.60) | KARS1 | |
| SCHEMBL901863 | 0.82 | KARS1 (0.56) | KARS1 | |
| SCHEMBL1704573 | 0.82 | KARS1 (0.73) | KARS1 | |
| SCHEMBL1704395 | 0.82 | KARS1 (0.53) | KARS1SYKGAA | |
| SCHEMBL902144 | 0.81 | KARS1 (0.59) | KARS1SYK | |
| SCHEMBL901935 | 0.81 | KARS1 (0.65) | KARS1 | |
| SCHEMBL901801 | 0.81 | KARS1 (0.56) | KARS1CYP3A4CYP2D6CYP2C9GRIN2B | |
| SCHEMBL901421 | 0.80 | KARS1 (0.82) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |