Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 10/20 | 0.46 |
| ▸ | CNR1 | P21554 | 8/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9029651 | 1.00 | CNR2 (0.46) | CNR2CNR1EGFRPPARGPPARD | |
| SCHEMBL13947388 | 0.83 | EGFR (0.48) | CNR2CNR1EGFRLMNATRPA1 | |
| SCHEMBL6748643 | 0.83 | EGFR (0.48) | CNR2CNR1EGFRLMNATRPA1 | |
| SCHEMBL6552685 | 0.83 | EGFR (0.48) | CNR2CNR1EGFRLMNATRPA1 | |
| SCHEMBL1700981 | 0.80 | EGFR (0.54) | EGFRLMNARAB9AEPHX1POLB | |
| SCHEMBL2534565 | 0.80 | EGFR (0.54) | EGFRLMNARAB9AEPHX1POLB | |
| SCHEMBL17197995 | 0.79 | CNR2 (0.45) | CNR2CNR1PPARGPPARDPPARA | |
| SCHEMBL22459199 | 0.77 | CNR2 (0.36) | CNR2CNR1EGFRPPARGPPARD | |
| SCHEMBL22793994 | 0.74 | CNR1 (0.33) | CNR2CNR1 | |
| SCHEMBL29615035 | 0.74 | CNR2 (0.68) | CNR2CNR1PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609289-B1 | IMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | UPJOHN CO (US) | 1996-07-17 | — | — | EP | disclosed |
| US-5442062-A | Treating hypertension, congestive heart failure | THE UPJOHN COMPANY (US) | 1995-08-15 | — | — | US | disclosed |
| EP-0609289-A1 | IMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. | UPJOHN CO (US) | 1994-08-10 | — | — | EP | disclosed |
| EP-0540209-A1 | Imidazole derivatives and pharmaceutical compositions containing the same | THE UPJOHN COMPANY (US) | 1993-05-05 | — | — | EP | disclosed |
| WO-1993008193-A1 | IMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | THE UPJOHN COMPANY (US) | 1993-04-29 | — | — | WO | disclosed |