Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 2/20 | 0.32 |
| ▸ | CES1 | P23141 | 2/20 | 0.32 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 3/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21331854 | 0.87 | HSD11B1 (0.35) | HSD11B1ALDH1A1SMN1; SMN2CCR2L3MBTL1 | |
| SCHEMBL9458297 | 0.85 | APP (0.33) | CYP2C19 | |
| Benzene SCHEMBL28354853 | 0.84 | HDAC4 (0.41) | HSD11B1LMNAOPRM1OPRL1 | |
| SCHEMBL4451679 | 0.84 | HDAC4 (0.41) | HSD11B1LMNAOPRM1OPRL1 | |
| SCHEMBL2783202 | 0.83 | TSHR (0.40) | ALDH1A1SMN1; SMN2CES2CES1SRD5A2 | |
| SCHEMBL9121052 | 0.83 | HSD11B1 (0.35) | HSD11B1L3MBTL1OPRM1 | |
| SCHEMBL1252354 | 0.80 | KDM4E (0.34) | SMN1; SMN2CYP2C19 | |
| SCHEMBL8429154 | 0.80 | BCL2L1 (0.40) | SRD5A2LMNA | |
| SCHEMBL3836530 | 0.75 | HDAC4 (0.39) | HSD11B1OPRM1OPRL1 | |
| SCHEMBL28755670 | 0.74 | HDAC4 (0.39) | CCR2OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0542554-B1 | Substituted N-biphenylyl lactams | ORTHO PHARMA CORP (US) | 1996-01-31 | — | — | EP | disclosed |
| US-5246940-A | Angoitensin II receptor antagonist for hypertension, stroke or diabetes | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-09-21 | — | — | US | disclosed |
| EP-0542554-A1 | Substituted N-biphenylyl lactams | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-19 | — | — | EP | disclosed |
| US-5182288-A | Angiotensin II receptor antagonists | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-01-26 | — | — | US | disclosed |