Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 16/20 | 0.78 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755676 | 0.91 | KARS1 (0.66) | KARS1PRKD1PRKD2PRKD3 | |
| SCHEMBL901557 | 0.90 | KARS1 (0.65) | KARS1CASP3SENP7NPC1RAB9A | |
| SCHEMBL901620 | 0.88 | KARS1 (1.00) | KARS1PRKD1PRKD2PRKD3 | |
| SCHEMBL901595 | 0.87 | KARS1 (0.86) | KARS1PRKD1PRKD2PRKD3 | |
| SCHEMBL1704268 | 0.87 | KARS1 (1.00) | KARS1PRKD1PRKD2PRKD3 | |
| SCHEMBL901763 | 0.87 | KARS1 (1.00) | KARS1PRKD1PRKD2 | |
| SCHEMBL1704280 | 0.86 | KARS1 (0.58) | KARS1 | |
| SCHEMBL901742 | 0.86 | KARS1 (1.00) | KARS1PRKD1PRKD2 | |
| SCHEMBL902055 | 0.85 | KARS1 (0.88) | KARS1PRKD1PRKD2 | |
| SCHEMBL901905 | 0.85 | KARS1 (0.80) | KARS1PRKD1PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |