Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902993 | 0.90 | KARS1 (0.78) | KARS1SMN1; SMN2RAB9ACASP3SENP7 | |
| SCHEMBL1704280 | 0.90 | KARS1 (0.58) | KARS1MAPTKDM4EHSD17B10MEN1 | |
| SCHEMBL901421 | 0.88 | KARS1 (0.82) | KARS1 | |
| SCHEMBL901833 | 0.87 | KARS1 (0.72) | KARS1SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL901791 | 0.87 | KARS1 (0.81) | KARS1 | |
| SCHEMBL902036 | 0.86 | KARS1 (0.81) | KARS1MAPTMEN1KMT2AHTT | |
| SCHEMBL902079 | 0.86 | KARS1 (0.70) | KARS1MEN1KMT2A | |
| SCHEMBL901962 | 0.85 | KARS1 (0.66) | KARS1RAB9ANPC1 | |
| SCHEMBL901973 | 0.85 | KARS1 (0.69) | KARS1MAPTRAB9ATP53NPC1 | |
| SCHEMBL901757 | 0.84 | KARS1 (0.66) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |