Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA7 | P43166 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24718232 | 0.80 | ALDH1A1 (0.53) | KDM4ETSHRALDH1A1HSD17B10CA12 | |
| SCHEMBL7443982 | 0.78 | TSHR (0.49) | KDM4ETSHRALDH1A1HSD17B10CA12 | |
| SCHEMBL24717740 | 0.77 | TSHR (0.47) | KDM4ETSHRALDH1A1HSD17B10CA12 | |
| SCHEMBL7438131 | 0.75 | KDM4E (0.43) | KDM4ETSHRALDH1A1HSD17B10CA12 | |
| SCHEMBL4626796 | 0.73 | METAP2 (0.46) | KDM4ETSHRALDH1A1HSD17B10CA12 | |
| SCHEMBL26126976 | 0.73 | TSHR (0.50) | KDM4ETSHRALDH1A1HSD17B10CA12 | |
| SCHEMBL6600799 | 0.73 | TSHR (0.65) | KDM4ETSHRALDH1A1HSD17B10LMNA | |
| SCHEMBL11296630 | 0.72 | TSHR (0.63) | KDM4ETSHRALDH1A1HSD17B10CA12 | |
| SCHEMBL28161602 | 0.71 | TSHR (0.65) | KDM4ETSHRALDH1A1HSD17B10CA12 | |
| SCHEMBL301812 | 0.71 | TSHR (0.55) | KDM4ETSHRALDH1A1HSD17B10CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741715-A1 | NOVEL HUMAN LEUKOCYTE ELASTASE (HLE) INHIBITORS, AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SRI INTERNATIONAL (US) | 1996-11-13 | — | — | EP | disclosed |