Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 8/20 | 0.56 |
| ▸ | AGTR1 | P30556 | 8/20 | 0.54 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL976 | 0.90 | GP6 (0.64) | AGTR2AGTR1GP6 | |
| SCHEMBL9284101 | 0.89 | AGTR2 (0.55) | AGTR2AGTR1GP6 | |
| SCHEMBL9198036 | 0.89 | AGTR2 (0.58) | AGTR2AGTR1GP6 | |
| SCHEMBL7362569 | 0.88 | AGTR2 (0.72) | AGTR2AGTR1GP6 | |
| SCHEMBL9205340 | 0.86 | AGTR2 (0.73) | AGTR2AGTR1GP6 | |
| SCHEMBL39 | 0.86 | AGTR2 (0.54) | AGTR2AGTR1GP6 | |
| SCHEMBL8265399 | 0.86 | AGTR2 (0.55) | AGTR2AGTR1GP6 | |
| SCHEMBL9595906 | 0.85 | AGTR2 (0.61) | AGTR2AGTR1GP6 | |
| SCHEMBL860 | 0.84 | GP6 (0.72) | AGTR2AGTR1GP6 | |
| SCHEMBL9031013 | 0.84 | AGTR2 (0.57) | AGTR2AGTR1GP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0479903-B1 | SUBSTITUTED IMIDAZOLES USEFUL AS ANGIOTENSIN II BLOCKERS | DU PONT (US) | 1996-02-21 | — | — | EP | disclosed |
| US-5354867-A | Hypertensive agents; congestive heart failure; used with diuretics to enhance activity; used with NSAIDs to prevent renal failure | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1994-10-11 | — | — | US | disclosed |
| WO-1991000277-A1 | SUBSTITUTED IMIDAZOLES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-01-10 | — | — | WO | disclosed |