Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.40 |
| ▸ | PPARA | Q07869 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 7/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9030724 | 1.00 | PPARG (0.40) | PPARGPPARAALDH1A1MAPTTDP1 | |
| SCHEMBL9030030 | 0.90 | PPARG (0.41) | PPARGPPARAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9030024 | 0.90 | PPARG (0.41) | PPARGPPARAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9031920 | 0.90 | PPARG (0.40) | PPARGPPARAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL9031929 | 0.90 | PPARG (0.40) | PPARGPPARAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL9030799 | 0.89 | PPARG (0.41) | PPARGPPARAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9030810 | 0.89 | PPARG (0.41) | PPARGPPARAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9032269 | 0.83 | KMT2A (0.35) | PPARGPPARAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9032281 | 0.83 | KMT2A (0.35) | PPARGPPARAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9031900 | 0.77 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558287-B1 | Tetrahydrothiophene derivatives | SANTEN PHARMACEUTICAL CO LTD (JP) | 1996-12-04 | — | — | EP | disclosed |
| US-5292767-A | Tetrahydrothiophene derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| EP-0558287-A1 | Tetrahydrothiophene derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1993-09-01 | — | — | EP | disclosed |