Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1257997 | 0.86 | ACHE (0.57) | SLC6A3SLC6A4ACHEHDAC1HDAC7 | |
| SCHEMBL14597968 | 0.83 | HDAC1 (0.67) | HDAC1HDAC7CASP3KMT2AMEN1 | |
| SCHEMBL3664093 | 0.83 | TSHR (0.55) | ACHEAGTR1AGTR2 | |
| SCHEMBL1206178 | 0.82 | KMT2A (0.58) | HDAC1HDAC7CASP3HDAC4HDAC8 | |
| SCHEMBL8539999 | 0.81 | SLC6A3 (0.69) | SLC6A3SLC6A4ACHESLC6A2AGTR1 | |
| SCHEMBL14326964 | 0.81 | SLC6A3 (0.69) | SLC6A3SLC6A4ACHESLC6A2AGTR1 | |
| SCHEMBL3112718 | 0.81 | SLC6A3 (0.69) | SLC6A3SLC6A4SLC6A2KMT2AAGTR1 | |
| SCHEMBL29979869 | 0.81 | SLC6A3 (0.69) | SLC6A3SLC6A4ACHESLC6A2AGTR1 | |
| SCHEMBL2642187 | 0.80 | SLC6A3 (0.67) | SLC6A3SLC6A4SLC6A2AGTR1AGTR2 | |
| SCHEMBL6478795 | 0.80 | MAPK1 (0.58) | HDAC1HDAC7CASP3HDAC4HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0542554-B1 | Substituted N-biphenylyl lactams | ORTHO PHARMA CORP (US) | 1996-01-31 | — | — | EP | disclosed |
| US-5246940-A | Angoitensin II receptor antagonist for hypertension, stroke or diabetes | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-09-21 | — | — | US | disclosed |
| EP-0542554-A1 | Substituted N-biphenylyl lactams | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-05-19 | — | — | EP | disclosed |
| US-5182288-A | Angiotensin II receptor antagonists | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-01-26 | — | — | US | disclosed |